Cytotoxicity and antiestrogenicity of a novel series of basic diphenylethylenes

J Gilbert, M Fuentes, T Ojasoo, JC Doré…

文献索引：Gilbert, Jacques; Fuentes, Maryse; Ojasoo, Tiiu; Dore, Jean-Christophe; Pons, Michel Journal of Medicinal Chemistry, 1997 , vol. 40, # 7 p. 1104 - 1111

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被引用次数: 20

摘要

On the premise that it is necessary to develop antiestrogens with a higher cytotoxic component in order to reduce the risks of the development of heterogeneous malignant cell populations in breast cancer, we studied a novel series of basic diphenylethylenes, for the most part devoid of estrogenic activity, with low antiestrogenicity but much enhanced cytotoxicity compared to the reference drug tamoxifen. The main structural features ...