Synthesis and protein conjugation studies of vitamin K analogues

RJ Payne, AM Daines, BM Clark, AD Abell

文献索引：Payne, Richard J.; Daines, Alison M.; Clark, Bruce M.; Abell, Andrew D. Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 22 p. 5785 - 5791

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被引用次数: 8

摘要

Two vitamin K analogues bearing a carboxylic acid side chain (9a and its deuterated analogue 9b) were each synthesised in six steps from commercially available menadione. Analogue 9b was conjugated to lysozyme and bovine serum albumin (BSA) using EDCI/HOBT and by prior formation of its activated succinimidyl ester 11. Quantification of the thus formed conjugates by ESMS and LC–MS revealed that the number of equivalents of ...