Tetrahedron letters

Obtention d'amino-2 thiazoles-1, 3 par action d'amines primaires sur des α-halo β-thiocyanato alcenes

M Giffard, J Cousseau

文献索引：Giffard, Michel; Cousseau, Jack Tetrahedron Letters, 1983 , vol. 24, # 46 p. 5085 - 5088

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被引用次数: 3

摘要

Abstract Action of primary amines on vic-halo-thiocyanato alkenes R 1-C (-SCN)= CX-R 2 affords 2-amino 1, 3-thiazoles, the cyclisation taking place with migration of the sulphur altom on the C C bond; thus 2-cyclohexylamino 5-propyl 1, 3-thiazole is obtained from 2- bromo 1-thiocyanato 1-pentene and cyclohexylamine.