Addition of thiols to o-quinone methide: New 2-hydroxy-3-phenylsulfanylmethyl [1, 4] naphthoquinones and their activity against the human malaria parasite …
…, P Gaur, VF Ferreira, CRS Garcia, DR Da Rocha
文献索引：Sharma, Abhinay; Santos, Isabela O.; Gaur, Pratibha; Ferreira, Vitor F.; Garcia, Celia R.S.; Da Rocha, David R. European Journal of Medicinal Chemistry, 2013 , vol. 59, p. 48 - 53
A series of 36 new phenylsulfanylmethyl [1, 4] naphthoquinones (7–42) were synthesized by a three-component reaction that involves lawsone, the appropriate aldehyde and thiols with variable substitution patterns. These reactions involve the in situ generation of o-quinone methides (o-QM) via Knoevenagel condensation and 1, 4-nucleophilic addition under conventional heating or microwave irradiation. The new naphthoquinones obtained by ...
