Tetrahedron

Ligand exchange reaction of sulfoxides in organic synthesis: A new synthesis of α-chloroketones from carbonyl compounds with one-carbon homologation

T Satoh, Y Mizu, T Kawashima, K Yamakawa

文献索引：Satoh Tsuyoshi; Mizu, Yasuhiro; Kawashima, Taku; Yamakawa, Koji Tetrahedron, 1995 , vol. 51, # 3 p. 703 - 710

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被引用次数: 39

摘要

A new procedure for one-carbon homologation of carbonyl compounds to α-chloroketones is described. Addition of the carbanion of dichloromethyl phenyl sulfoxide with ketones and aldehydes gave the adducts, chloro alcohols, in good yields. Treatment of the chloro alcohols with EtMgBr or lithium diisopropylamide gave one-carbon homologated α- chloroketones via β-oxido carbenoid rearrangement in moderate to good yields. One- ...