Tetrahedron Letters

Three-component sequential synthesis of N, N′-disubstituted 5-arylidenedihydropyrimidine-2, 4-dione

MC Bellucci, A Volonterio

文献索引：Bellucci, Maria Cristina; Volonterio, Alessandro Tetrahedron Letters, 2012 , vol. 53, # 35 p. 4733 - 4737

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被引用次数: 3

摘要

A three-component sequential process consisting in (1) in situ formation of carbodiimides by Staudinger reaction,(2) reaction with 2-(bromomethyl)-3-aryl-2-propenoic acids, and (3) final cyclization of the resulting N-acylurea intermediates in order to obtain the synthesis of an array of N, N′-disubstituted 5-arylidenedihydropyrimidine-2, 4-dione under mild conditions is presented.