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5-Arylthiopyrimidines. I. 2, 4-diamino derivatives

EA FALCO, B ROTH…

文献索引:Falco,E.A. et al. Journal of Organic Chemistry, 1961 , vol. 26, p. 1143 - 1146

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被引用次数: 13

摘要

Arylmercaptoacetonitrilea are readily acylated with lower aliphatic eaters. Their crude enol ethers, obtained by reaction with diasomethane, condense with guanidine to produce 2, 4- diamincl. 5srylmercaptop~~ dines. In contrast with the closely related 5-phenoxy-and 5benaylpyrimidinea, these compounds are practically devoid of activity us. protozoan and bacterial infections. However, several members of the seriea are central nervous system ...