Analogs of Nucleotides. II. Phosphonate Esters of Ribose and Glucopyranosyl Purine Derivatives1

JR Parikh, ME Wolff, A Burger

文献索引：Parikh et al. Journal of the American Chemical Society, 1957 , vol. 79, p. 2778,2781

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被引用次数: 33

摘要

The amorphous 1-chloro derivative obtained by treating IV with ethereal hydrogen chloride at 0" could not be condensed with either silver theophylline, or with 6-chloropurine mercuri chloride, although the reactivity of the l-chlorine atom in a highly substituted ribose derivative was demonstrated by condensing 2, 3, 5-tri-O-benzoyl-~-ribo-f uranosyl chloride6 with silver theophylline to yield 7-(2, 3, 5-tri-0-benzoyl-~-~-ribofuranosyl)-theophylline (V).