Helvetica chimica acta

Synthesis, CD Spectra, and Enzymatic Stability of β2??Oligoazapeptides Prepared from (S)??2??Hydrazino Carboxylic Acids Carrying the Side Chains of Val, Ala, and …

G Lelais, D Seebach

文献索引：Lelais, Gerald; Seebach, Dieter Helvetica Chimica Acta, 2003 , vol. 86, # 12 p. 4152 - 4168

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被引用次数: 84

摘要

Abstract β-Peptides offer the unique possibility to incorporate additional heteroatoms into the peptidic backbone (Figs. 1 and 2). We report here the synthesis and spectroscopic investigations of β 2-peptide analogs consisting of (S)-3-aza-β-amino acids carrying the side chains of Val, Ala, and Leu. The hydrazino carboxylic acids were prepared by a known method: Boc amidation of the corresponding N-benzyl-L-α-amino acids with an ...