We recently needed a general method for functionalization of the C??3 position of isoindazoles (also called 2H??indazoles). A perusal of the literature revealed that this position can be metalated with alkyllithium reagents, and the resulting organolithium species then reacted with electrophiles.1 View all references This method appeared to us to be the most suitable of the limited number of examples that we found (For a review on the chemistry of indazoles and ...
