Pharmaceutical chemistry journal

Alternate synthesis for Diazoline

YM Yutilov, NN Smolyar, AS Volchkov

文献索引：Yutilov; Smolyar; Volchkov Pharmaceutical Chemistry Journal, 2000 , vol. 34, # 12 p. 661 - 662

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被引用次数: 4

摘要

Synthesis of 3-methyl-9-benzyl-1, 2, 3, 4-tetrahydro-γ-carboline, which is the active principle of the familiar antihistamine drug diazoline [1], is carried out via a Fischer reaction from 1- methyl-4-piperidone and benzylphenylhydrazine [2]. In turn, methylpiperidone is obtained by