The biosynthesis of the fungal metabolite oudenone (1) was investigated in cultures of Oudemamiella radicata. Feeding experiments using 13C-and 2H-labeled precursors, as well as NMR analyses of the labeled metabolite, suggested a polyketide origin. The incorporation of six acetate units into the carbon skeleton of 1 was observed when cultures were fed the N-acetylcysteamine thioester derivative of 13C-labeled acetate. Labeling of ...
