Tetrahedron letters

A simple synthetic protocol for oxidation of alkyl-arenes into ketones using a combination of HBr–H 2 O 2

AT Khan, T Parvin, LH Choudhury, S Ghosh

文献索引：Khan, Abu T.; Parvin, Tasneem; Choudhury, Lokman H.; Ghosh, Subrata Tetrahedron Letters, 2007 , vol. 48, # 13 p. 2271 - 2274

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被引用次数: 26

摘要

A wide variety of alkyl-and cycloalkyl-arenes undergo benzylic C–H oxidation by employing a combination of 48% hydrogen bromide and 30% hydrogen peroxide in dichloromethane at room temperature. In addition, a chemoselective oxidation at the benzylic position is feasible by deactivating the aromatic ring using the same combination.