Tetrahedron

Copper (II) acetate-catalyzed one-pot conversion of aldehydes into primary amides through a Beckmann-type rearrangement

A Martínez-Asencio, M Yus, DJ Ramón

文献索引：Martinez-Asencio, Ana; Yus, Miguel; Ramon, Diego J. Tetrahedron, 2012 , vol. 68, # 21 p. 3948 - 3951

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被引用次数: 28

摘要

Copper (II) acetate is a versatile catalyst for the direct transformation of any type of aldehydes into primary amides by stoichiometric reaction with hydroxylamine in water. The catalyst could be recovered 10 times without losing its activity, just by a simple organic layer extraction of the product. The catalyst and the protocol avoid the use of any type of expensive and difficult to handle organic ligand, as well as bases, showing excellent ...