A novel series of selective, non-peptide inhibitors of angiotensin II binding to the AT2 site

MK VanAtten, CL Ensinger, AT Chiu…

文献索引：VanAtten, Mary K.; Ensinger, Carol L.; Chiu, Andrew T.; McCall, Dale E.; Nguyen, Tam T.; et al. Journal of Medicinal Chemistry, 1993 , vol. 36, # 25 p. 3985 - 3992

全文：HTML全文

被引用次数: 26

摘要

The availability of peptide and non-peptide Ang I1 receptor antagonists has permitted the study of Ang I1 receptor heterogeneity. It is now widely recognized that there are at least two distinct Ang I1 receptor subtypes. AT1 receptors are selective in their recognition of agents such as losartan, DuP 532, L-158,809, SKkF108566, and similar non-peptides. To date, all of the well-known actions of Ang I1 in mammals are blocked by the AT1 selective ...