Tetrahedron letters

A simple synthetic protocol for the protection of amides, lactams, ureas, and carbamates

…, RL Hudkins, PA Messina-McLaughlin, JP Mallamo

文献索引：Reddy, Dandu R; Iqbal, Mohamed A; Hudkins, Robert L; Messina-McLaughlin, Patricia A; Mallamo, John P Tetrahedron Letters, 2002 , vol. 43, # 45 p. 8063 - 8066

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被引用次数: 19

摘要

A new procedure for protecting the amide, lactam, urea, and carbamate NH group with a triphenylmethyl (Tr) group is described. The utility of this method is illustrated with molecules that contain other functional groups. A mild deprotection using trifluoroacetic acid makes this a useful method for attaching amide groups on resin for combinatorial synthesis.