Natural product derived antiprotozoal agents: synthesis, biological evaluation, and structure–activity relationships of novel chromene and chromane derivatives

…, H Prinz, R Brun, TJ Schmidt…

文献索引：Harel, Dipak; Khalid, Sami A.; Kaiser, Marcel; Brun, Reto; Wuensch, Bernhard; Schmidt, Thomas J. Journal of Ethnopharmacology, 2011 , vol. 137, # 1 p. 620 - 625

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被引用次数: 15

摘要

Various natural products with the chromane and chromene scaffold exhibit high antiprotozoal activity. The natural product encecalin (7) served as key intermediate for the synthesis of different ethers 9, amides 11, and amines 12. The chromane analogues 14 and