Abstract Some new 6-amino-1, 3-dimethyl-5-(substituted methylidene) aminouracils were synthesized. Most of them were cyclized with triethyl orthoformate as a one-carbon source to afford 1, 3-dimethyl-6-substituted pteridine derivatives. Certain uracils gave xanthine instead of the expected pteridine derivatives upon using another one-carbon source such as triethyl orthoacetate or triethyl orthobenzoate. The nucleic acid binding assay revealed that some ...