Synthesis, DNA binding and antiviral activity of new uracil, xanthine, and pteridine derivatives

…, ME El??Sadek, S El??Kalyoubi, I Ismail

文献索引：El-Sabbagh, Osama I.; El-Sadek, Mohamed E.; El-Kalyoubi, Samar; Ismail, Ibrahim Archiv der Pharmazie, 2007 , vol. 340, # 1 p. 26 - 31

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被引用次数: 5

摘要

Abstract Some new 6-amino-1, 3-dimethyl-5-(substituted methylidene) aminouracils were synthesized. Most of them were cyclized with triethyl orthoformate as a one-carbon source to afford 1, 3-dimethyl-6-substituted pteridine derivatives. Certain uracils gave xanthine instead of the expected pteridine derivatives upon using another one-carbon source such as triethyl orthoacetate or triethyl orthobenzoate. The nucleic acid binding assay revealed that some ...