Abstract: Of several routes explored for the synthesis of 3-amino-2, 3, 6-trideoxyhexoses such as L-acosamine (L-arabino), two versions of the nitroaldol strategy were completed. The silyl nitronate approach with use of" anhydrous" tetrabutylammonium fluoride (Bu4NF) turned out to be rather complex, since the key step led to a moderately diastereoselective, though still efficient solution. In a simpler mode, with Bu4NF trihydrate as a catalyst, the ...
