Pinacolborane as the Boron Source in Nitrogen-Directed Borylations of Aromatic N, N-Dimethylhydrazones

R López-Rodríguez, A Ros, R Fernández…

文献索引：Ros, Abel; Lopez-Rodriguez, Rocio; Estepa, Beatriz; Alvarez, Eleuterio; Fernandez, Rosario; Lassaletta, Jose M. Journal of the American Chemical Society, 2012 , vol. 134, # 10 p. 4573 - 4576

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被引用次数: 17

摘要

A mild procedure for the Ir (III)-catalyzed nitrogen-directed ortho borylation of aromatic N, N- dialkylhydrazones using pinacolborane as the boron source has been developed. The methodology relies on a modified, hemilabile N, N ligand built on a 4-N, N- dimethylaminopyridine unit that provides high reactivity while maintaining exclusive ortho- selectivity. This procedure can be combined with Suzuki–Miyaura cross-couplings in a ' ...