A facile protocol for N-Cbz protection of amines in PEG-600

…, DF Zhang, HY Zhao, ZY Lin, HH Huang

文献索引：Zhang, Chun Lin; Zhang, Dong Feng; Zhao, Hong Yi; Lin, Zi Yun; Huang, Hai Hong Chinese Chemical Letters, 2012 , vol. 23, # 7 p. 789 - 792

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被引用次数: 1

摘要

An efficient and eco-friendly protocol for the chemoselective N-benzyloxycarbonylation of amines was described. The reaction of amines with benzyl chloroformate (Cbz-Cl) in the presence of PEG-600 at room temperature afforded the corresponding N-Cbz derivatives in excellent yields. The method is applicable to the N-Cbz protection of aliphatic (acyclic and cyclic) and aromatic amines.