Synthesis of novel imidazobenzodiazepines as probes of the pharmacophore for" diazepam-insensitive" GABAA receptors

…, W Zhang, R Liu, B Harris, P Skolnick…

文献索引：Zhang, Puwen; Zhang, Weijiang; Liu, Ruiyan; Harris, Bradford; Skolnick, Phil; Cook, James M. Journal of Medicinal Chemistry, 1995 , vol. 38, # 10 p. 1679 - 1688

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被引用次数: 47

摘要

The syntheses of a series of novel imidazobenzodiazepines and their affinities for diazepam sensitive (DS) and diazepam insensitive (DI) GABAA receptors are described. Imidazobenzodiazepines belong to one of the very few chemical families which exhibit high to moderate potency for DI GABAA receptors. Although imidazobenzodiazepines such as Ro 15-4513, 20, are the most potent DI GABAA receptor ligands described to date, their ...