3-Azaphenothiazine and dialkylaminoalkyl derivatives

FH CLARKE, GB SILVERMAN…

文献索引：Clarke,F.H. et al. Journal of Organic Chemistry, 1961 , vol. 26, p. 1126 - 1132

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被引用次数: 19

摘要

The pharmacological evaluation of 3-(3dimethylaminopropyl)-3-azaphenothiazinium chloride hydrochloride (V chloride hydrochloride) showed it to be a potent hypotensive agent. The intravenous injection of a dose of 2 mg./kg. caused a marked fall in the blood pressure of phenobarbital-anesthetized dogs which lasted for about one hour. In order to study further the hypotensive activity of this class of compounds a number of analogues ...