A Facile Synthesis of (E, Z)??3??Chloro??2??propenamides, Acids, and Esters from 2, 3??Acetylenic Acids with Oxalyl Chloride in DMF

NA Urdaneta, J Salazar, JC Herrera…

文献索引：Urdaneta, Neudo A.; Herrera, Julio C.; Salazar, Jose; Lopez, Simon E. Synthetic Communications, 2002 , vol. 32, # 19 p. 3003 - 3009

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被引用次数: 5

摘要

Abstract A simple route is described for the synthesis of E and Z 3??chloro??2??propenamides (4a??e), esters (3a) and acids (2a??c) by the reaction of 2, 3??acetylenic acids with oxalyl chloride in DMF followed by treatment of the corresponding 3??chloro??2??propenoyl chloride derivative with amines, alcohol and water.