Resolution of racemic carbocyclic analogs of purine nucleosides through the action of adenosine deaminase. Antiviral activity of the carbocyclic 2'-deoxyguanosine …

…, JA Montgomery, YF Shealy, CA O'Dell…

文献索引：Secrist III.; Montgomery; Shealy; O'Dell; Clayton Journal of Medicinal Chemistry, 1987 , vol. 30, # 4 p. 746 - 749

全文：HTML全文

被引用次数: 43

摘要

The action of adenosine deaminase on racemic carbocyclic analogues of 6-aminopurine nucleosides was investigated. When either racemic carbocyclic adenosine [(*)-C-Ado] or the racemic carbocyclic analogue [(h)-C-2, 6-DAP-2'-dR] of 2, 6-diaminopurine 2'- deoxyribofuranoside was incubated with this enzyme, approximately half of the material was deaminated rapidly. From the resulting solution, the D isomers of the deaminated ...