Synthesis and neuroprotective effect of E-3, 4-dihydroxy styryl aralkyl ketones derivatives against oxidative stress and inflammation

X Ning, Y Guo, X Ma, R Zhu, C Tian, X Wang…

文献索引：Ning, Xianling; Guo, Ying; Ma, Xiaoyan; Zhu, Renzong; Tian, Chao; Wang, Xiaowei; Ma, Zhizhong; Zhang, Zhili; Liu, Junyi Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 13 p. 3700 - 3703

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被引用次数: 6

摘要

E-3, 4-Dihydroxy styryl aralkyl ketones as well as their 3, 4-diacetylated derivatives as the analogues of neuroprotective agent CAPE were designed and synthesized for improving stability and lipid solubility. The neuroprotective activities of target compounds 10a–g and 11a–g were tested by three models in vitro, including 1, 1-diphenyl-2-picrylhydrazyl radical scavenging capacity, neuronal protecting effect against damage induced by H2O2 in ...