Solvent-free synthesis of 2', 3', 5'-tri-O-acetyl-2, 6-dichloropurine nucleoside catalyzed by p-toluenesulfonic acid using microwave

G Qu, Q Liu

文献索引：Qu, Guirong; Liu, Qibin Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2005 , vol. 44, # 1 p. 196 - 197

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被引用次数: 9

摘要

Abstract: Starting from tetraacetylribofuranose 1 and 2, 6-dichloropurine 2, in the presence of p-toluenesulfonic acid (p-TsOH), 2′, 3′, 5′-tri-O-acetyl-2, 6-dichloropurine nucleoside 3 has been synthesized in microwave oven for the first time. On comparing (→ Comparing) with the conventional methods, this method has advantages such as shorter reaction time (4.5 min), better yield (83.5%), simple (→ simpler) workup and environmental acceptability.