2-Oxoglutarate analogue inhibitors of prolyl hydroxylase domain 2

…, C Loenarz, R Chowdhury, CJ Schofield

文献索引：Mecinovic, Jasmin; Loenarz, Christoph; Chowdhury, Rasheduzzaman; Schofield, Christopher J. Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 21 p. 6192 - 6195

全文：HTML全文

被引用次数: 26

摘要

Analogues of the 2-oxoglutarate cosubstrate of the human oxygen sensing enzyme prolyl hydroxylase domain 2 (PHD2) with variations in the potential iron-chelating group were screened as inhibitors and for binding (using non-denaturing electrospray ionization mass spectrometry) to PHD2.