A Facile Chemoenzymatic Approach: One??Step Syntheses of Monoterpenoid Indole Alkaloids

…, L Zhang, LQ Yang, YP Yu, J Stöckigt

文献索引：Zou, Hong-Bin; Zhu, Hua-Jian; Zhang, Liang; Yang, Liu-Qing; Yu, Yong-Ping; Stoeckigt, Joachim Chemistry - An Asian Journal, 2010 , vol. 5, # 11 p. 2400 - 2404

全文：HTML全文

被引用次数: 11

摘要

Abstract Facile chemoenzymatic syntheses of cytotoxic monoterpenoid indole alkaloids with novel skeletons and multiple chiral centers are described. Synthesis of these alkaloids was achieved by a simple one-step reaction using strictosidine and 12-aza-strictosidine as the key intermediates. Strictosidines were prepared by coupling of secologanin with tryptamine and 7-aza-tryptamine, respectively, using the immobilized recombinant Rauvolfia ...