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Structure-based design and synthesis of potent matrix metalloproteinase inhibitors derived from a 6 H-1, 3, 4-thiadiazine scaffold

J Schröder, A Henke, H Wenzel…

文献索引:Busby, Reginald E.; Dominey, Terence W. Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1980 , p. 890 - 899

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被引用次数: 82

摘要

... Journal of Medicinal ... Further chemical modifications including the lack of the 6-methyl group resulted in novel 6H-1,3,4 ... N'-(3-dimethylaminopropyl)-carbodiimide hydrochloride, 1-hydroxybenzotriazole, and 4-methylmorpholine in DMF at 5 °C. The compounds with the general ...