Organic letters

Mesityllithium as a reagent for chemoselective halogen-lithium exchange reaction

…, M Asai, T Miura, M Uchiyama, T Sakamoto

文献索引：Kondo; Asai; Miura; Uchiyama; Sakamoto Organic letters, 2001 , vol. 3, # 1 p. 13 - 15

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被引用次数: 51

摘要

Mesityllithium was found to be an excellent selective lithiating agent to prepare aryllithium compounds having alkoxycarbonyl groups. To extend our studies on chemoselective lithiation, an important precursor for the synthesis of camptothecin was prepared using a halogen-lithium exchange reaction followed by an intramolecular 1, 2-addition.