Synthesis of novel amino and acetyl amino-4-methylcoumarins and evaluation of their antioxidant activity

…, HG Raj, P Vohra, G Gupta, R Kumari, P Kumar…

文献索引：Tyagi, Yogesh K.; Kumar, Ajit; Raj, Hanumantharao G.; Vohra, Parag; Gupta, Garima; Kumari, Ranju; Kumar, Pankaj; Gupta, Rajinder K. European Journal of Medicinal Chemistry, 2005 , vol. 40, # 4 p. 413 - 420

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被引用次数: 109

摘要

The six novel 4-methylcoumarins bearing different functionalities such as amino, hydroxy, N- acetyl, acetoxy and nitro have been synthesized and confirmed on the basis of their spectral data (1H-, 13C-NMR, UV, IR and EI mass). They were examined for the first time for their effect on NADPH dependent liver microsomal lipid peroxidation in vitro, and the results were compared with other model 4-methylcoumarin derivatives to establish the structure– ...