Studies with plant cell cultures of Catharanthus roseus. Oxidative coupling of dibenzylbutanolides catalyzed by plant cell culture extracts

…, GM Hewitt, TC Jarvis, J Palaty…

文献索引：Kutney; Hewitt; Jarvis; Palaty; Rettig Canadian Journal of Chemistry, 1992 , vol. 70, # 7 p. 2115 - 2133

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被引用次数: 19

摘要

Utilizing appropriate dibenzylbutanolides, for example 7, obtained via an efficient synthetic route from readily available aldehydes, and cell-free extracts obtained from Catharanthus roseus cell cultures, it was possible to achieve enzyme-catalyzed oxidative coupling of 7 to picropodophyllotoxin analogues. Studies are presently underway to convert such compounds to intermediates employed in the synthesis of the commercially important anti- ...