Palladium-catalyzed direct arylation of polysubstituted benzofurans

…, JC Florent, P Rousselle, E Bertounesque

文献索引：Carrer, Amandine; Brinet, Dimitri; Florent, Jean-Claude; Rousselle, Patricia; Bertounesque, Emmanuel Journal of Organic Chemistry, 2012 , vol. 77, # 3 p. 1316 - 1327

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被引用次数: 28

摘要

An efficient access to 2-substituted 3-arylbenzofurans through a palladium-catalyzed C3 direct arylation of 2-substituted benzofurans with aryl bromides is described. The scope and limitation of this reaction was studied. The method tolerates a variety of functional groups on the aryl halide and has been successfully extended to polysubstituted benzofurans to obtain the corresponding 3-arylbenzofurans with good to excellent yields.