Reductive amination of ketones: novel one-step transfer hydrogenations in batch and continuous-flow mode

P Falus, Z Boros, G Hornyánszky, J Nagy, F Darvas…

文献索引：Falus, Peter; Boros, Zoltan; Hornyanszky, Gabor; Nagy, Jozsef; Darvas, Ferenc; Uerge, Laszlo; Poppe, Laszlo Tetrahedron Letters, 2011 , vol. 52, # 12 p. 1310 - 1312

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被引用次数: 17

摘要

Various ketones were efficiently transformed into the corresponding amines using ammonium formate in the presence of Zn dust or 10% Pd/C. The low-cost Zn dust method proved to be effective in amine formation from carbonyl groups at the benzylic side-chain position of aromatic systems, whereas 10% Pd/C was an efficient catalyst in the reductive aminations of carbonyl groups non-conjugated with any π-system. The 10% Pd/C- ...