Synthesis and pharmacological evaluation of sulfonium analogs of dopamine: nonclassical dopamine agonists

K Anderson, A Kuruvilla, N Uretsky…

文献索引：Anderson, Karen; Kuruvilla, Alice; Uretsky, Norman; Miller, Duane D. Journal of Medicinal Chemistry, 1981 , vol. 24, # 6 p. 683 - 687

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被引用次数: 23

摘要

In order to test whether the nitrogen/ammonium moiety in the dopamine molecule is required for dopaminergic activity, we have synthesized two sulfonium analogues of dopamine and tested them for biological activity in an in vivo and in an in vitro system. These analogues have provided a means of investigating (1) the ability of the sulfonium function to serve as a bioisostere for the dopamine amino group and (2) whether charged molecules have the ...