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Potential Purine Antagonists. VIII. The Preparation of Some 7-Methylpurines1

RN Prasad, RK Robins

文献索引:Prasad; Robins Journal of the American Chemical Society, 1957 , vol. 79, p. 6401,6405

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被引用次数: 55

摘要

(4) RK Robins and HH Lin, TIXIS JOURNAL, 79, 490 (1957). fore seemed desirable to prepare G-chloro-7-methylpurine (VI) as a candidate anti-tumor agent. Since preliminary methylation studies of 6-chloropurine gave a difficultly separable mixture of the 7-methyl and 9-methyl isomers, the possible preparation of 6-chloro-7-methylpurine (VI) from 7- methylhypoxanthine (V) was investigated. Earlier methods of preparation of 7- ...