The Reduction of Amides to Amines via Nitriles by Lithium Aluminum Hydride1

MS Newman, T Fukunaga

文献索引：Newman,M.S.; Fukunaga,T. Journal of the American Chemical Society, 1960 , vol. 82, p. 693 - 696

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被引用次数: 21

摘要

The reduction of unsubstituted amides to primary amines has often been accomplished by lithium aluminum hydride. 3 In discussion as to possible mechanisms for this type of reduction, attention has been directed to the nature of the complex hydride rather than to the organic moiety. With regard to the latter, it has been assumed that some species added to the carbonyl group as a first step.