Synthesis and antimalarial activity of dihydroperoxides and tetraoxanes conjugated with bis (benzyl) acetone derivatives

LL Franco, MV de Almeida, PPR Vieira…

文献索引：Franco, Lucas Lopardi; de Almeida, Mauro Vieira; e Silva, Luiz Francisco Rocha; Vieira, Pedro Paulo Ribeiro; Pohlit, Adrian Martin; Valle, Marcelo Siqueira Chemical Biology and Drug Design, 2012 , vol. 79, # 5 p. 790 - 797

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被引用次数: 19

摘要

Dihydroperoxides and tetraoxanes derived from symmetrically substituted bis (arylmethyl) acetones were synthesized in modest to good yields using several methods. Three of these compounds exhibit an important in vitro antimalarial activity (1.0 lM£ IC50£ 5.0 lM) against blood forms of the human malaria parasite Plasmodium falciparum. Key words: antiplasmodial, antiprotozoal, malaria, Plasmodium falciparum