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Synthesis, antimicrobial data and correlation analysis in a set of 2-alkyl-5-amidobenzotriazoles

…, G Sagliocco, V Santagada, C Silipo, A Vittoria

文献索引:Caliendo; Novellino; Sagliocco; Santagada; Silipo; Vittoria European Journal of Medicinal Chemistry, 1992 , vol. 27, # 2 p. 161 - 166

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被引用次数: 4

摘要

Abstract A set of 2-alkyl-5-amidobenzotriazoles has been prepared and characterized. Shake-flask partition coefficients (log P) and capacity factors (log k′) have been experimentally determined. The in vitro antimicrobial activity against Gram-positive, Gram- negative and Candida albicans have been correlated, through regression analysis, with the corresponding partition coefficients.