Chemical and pharmaceutical bulletin

Dianion of Sulfinylacetone as a Synthetic Equivalent of. BETA.-Enolate of Propionic Acid: A Novel Synthesis of Carboxylic Acids from Alkyl Halides with Three-Carbon …

T Satoh, K Imai

文献索引：Satoh, Tsuyoshi; Imai, Kentaro Chemical and Pharmaceutical Bulletin, 2003 , vol. 51, # 5 p. 602 - 604

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被引用次数: 4

摘要

The reaction of the dianion of phenylsulfinylacetone with alkyl halides afforded β-keto sulfoxides, which were first chlorinated with hexachloroethane and then treated successively with KH and t-BuLi to give carboxylic acids in three-steps in moderate overall yields from the alkyl halides. This procedure affords a good method for a synthesis of carboxylic acids from alkyl halides with three-carbon elongation.