Synthesis and evaluation of a photolyzable derivative of sphingosine 1-phosphate—caged SPP

L Qiao, AP Kozikowski, A Olivera, S Spiegel

文献索引：Qiao, Lixin; Kozikowski, Alan P.; Olivera, Ana; Spiegel, Sarah Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 7 p. 711 - 714

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被引用次数: 38

摘要

The synthesis of a photolyzable sphingosine 1-phosphate derivative is reported via the reaction of N-(tert-butoxycarbonyl)-2-N, 3-O-isopropylidenesphingosine7 and bis (α-methyl- o-nitrobenzyl) N, N-diisopropyl-phosphoramidite. Stimulation of DNA synthesis upon illumination of caged SPP-loaded cells is also described.