N-Arylsulfonamides have long been the subjects of pharmaceutical interest because of their potential biological activities. [ 1 1. ( a ) Harter , WG ; Albrect , H. ; Brady , K. ; Caprathe , B. ; Dunbar , J. ; Gilmore , J. ; Hays , S. ; Kostlan , CR ; Lunney , B. ; Walker , N. The design and synthesis of sulfonamides as caspase-1 inhibitors . Bioorg. Med. Chem. Lett. 2004 , 14 , 809 – 812 ; ( b ) Reddy , NSM ; Mallireddigari , R. ; Cosenza , KG ; Bell , SC ; Reddy , EP ; Reddy , MVR ...