Tetrahedron

Deamination of 5′-substituted-2′, 3′-isopropylidene adenosine derivatives catalyzed by adenosine deaminase (ADA, EC 3.5. 4.4) and complementary enzymatic …

P Ciuffreda, A Loseto, E Santaniello

文献索引：Ciuffreda, Pierangela; Loseto, Angela; Santaniello, Enzo Tetrahedron, 2002 , vol. 58, # 29 p. 5767 - 5771

全文：HTML全文

被引用次数: 32

摘要

Adenosine deaminase (ADA) catalyzes the deamination of 2′, 3′-isopropylidene adenosine and the corresponding 5′-amino derivative in a 3% dimethylsulfoxide aqueous solution. Whereas ADA is unable to convert other 5′-substituted derivatives (acetate, acetamido, azide), the enzyme adenylate deaminase (AMPDA) accepts all the above compounds as substrates for their biotransformation to the corresponding 5′-substituted ...