Tetrahedron

Efficient Synthesis of Resin-Bound α-TMSdiazoketones and Their Use in Solid-Phase Organic Synthesis

Y Iso, H Shindo, H Hamana

文献索引：Iso, Yasuyoshi; Shindo, Hirohisa; Hamana, Hiroshi Tetrahedron, 2000 , vol. 56, # 30 p. 5353 - 5361

全文：HTML全文

被引用次数: 29

摘要

α-TMSdiazoketones on a solid support could be simply and efficiently prepared by reaction of the corresponding resin-bound acid chlorides with excess TMSdiazomethane, without any bases. These α-TMSdiazoketones were used via carbenes or carbenoids for a variety of solid-phase reactions. These useful solid-phase reactions allow efficient construction of diverse compound libraries by use of combinatorial chemistry, due to the high reactivity ...