Novel Pyrazole and Indazole Derivatives: Synthesis and Evaluation of Their Anti??Proliferative and Anti??Angiogenic Activities

E Tzanetou, S Liekens, KM Kasiotis…

文献索引：Tzanetou, Evangelia; Liekens, Sandra; Kasiotis, Konstantinos M.; Fokialakis, Nikolas; Haroutounian, Serkos A. Archiv der Pharmazie, 2012 , vol. 345, # 10 p. 804 - 811

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被引用次数: 7

摘要

Abstract The synthesis of several new pyrazole and indazole derivatives from acetophenone and tetralone substrates is reported. The bioactivities of the new compounds were evaluated through in vitro assays for endothelial cell proliferation and tube formation. Results herein indicate that the easily prepared compounds containing the indazole structural framework exhibit potent cytostatic properties against all cell lines tested, with compounds 13 and 14 ...