Tetrahedron

Novel solid-supported dimerization–heteroannulation of chalcones: simple and efficient synthesis of 2, 4, 6-triaryl-3-methylarylpyridines

AK Verma, S Koul, APS Pannu, TK Razdan

文献索引：Verma, Anil K.; Koul, Summon; Pannu, Ajay P.S.; Razdan, Tej K. Tetrahedron, 2007 , vol. 63, # 36 p. 8715 - 8722

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被引用次数: 16

摘要

2, 4, 6-Triaryl-3-methylarylpyridines were obtained, in 60–70% yield, by a novel one-pot solventless solid-supported dimerization–heteroannulation reaction of chalcones and compounds possessing terminal–CONH2 functionality, at 125–135° C, using immobilized Bi (III) nitrate and Zn (II) chloride as co-catalyst. Initially, chalcones were prepared, in nearly quantitative yield, by a modified aldol condensation, in neutral aqueous medium, in the ...