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The Journal of organic chemistry

Generation and cyclization of a benzyne-tethered alkyllithium: preparation of 4-substituted indans

WF Bailey, SC Longstaff

文献索引:Bailey, William F.; Longstaff, Sarah C. Journal of Organic Chemistry, 1998 , vol. 63, # 3 p. 432 - 433

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被引用次数: 49

摘要

The intramolecular addition of an organolithium to a tethered benzyne intermediate, illustrated below, offers a conceptually simple route to functionalized benzo-fused carbocycles. Although intermolecular addition of an organolithium to a benzyne is a well characterized process, 1 and while intramolecular trapping of benzyne intermediates by tethered heteroatomic nucleophiles or a stabilized carbanions, first demonstrated by ...