Dynamic Enzymatic Kinetic Resolution of Methyl 2, 3??Dihydro??1H??indene??1??carboxylate

J Pietruszka, RC Simon, F Kruska…

文献索引：Pietruszka, Joerg; Simon, Robert Christian; Kruska, Fabian; Braun, Manfred European Journal of Organic Chemistry, 2009 , # 35 p. 6217 - 6224

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被引用次数: 15

摘要

Abstract A new reaction setup for kinetic enzymatic resolution was established and is demonstrated for the case of the hydrolase-catalysed conversion of methyl 2, 3-dihydro-1H- indene-1-carboxylate (1) in conjunction with a base-catalysed racemisation. The system allows controlled racemisation, resulting in efficient dynamic kinetic resolution (DKR) of the title compound. Short reaction times and high enantioselectivities were obtained with CAL ...