asparaginase

Modify Date: 2024-01-08 10:19:47

asparaginase Structure
asparaginase structure
Common Name asparaginase
CAS Number 9015-68-3 Molecular Weight 151.186
Density 1.4±0.1 g/cm3 Boiling Point 204.5±23.0 °C at 760 mmHg
Molecular Formula C7H5NOS Melting Point N/A
MSDS Chinese USA Flash Point 77.5±22.6 °C
Symbol GHS07 GHS08
GHS07, GHS08
Signal Word Warning

 Use of asparaginase


L-Asparaginase (L-​ASNase), a hydrolase that catalyzes the conversion of L-asparagine, used in acute lymphoblastic leukemia treatment. L-Asparaginase depletes L-asparagine from plasma resulting in inhibition of RNA and DNA synthesis with the subsequent blastic cell apoptosis[1].

 Names

Name L-Asparaginase
Synonym More Synonyms

 asparaginase Biological Activity

Description L-Asparaginase (L-​ASNase), a hydrolase that catalyzes the conversion of L-asparagine, used in acute lymphoblastic leukemia treatment. L-Asparaginase depletes L-asparagine from plasma resulting in inhibition of RNA and DNA synthesis with the subsequent blastic cell apoptosis[1].
Related Catalog
References

[1]. Piatkowska-Jakubas B, et al. Use of L-asparaginase in acute lymphoblastic leukemia: recommendations of the Polish Adult Leukemia Group. Pol Arch Med Wewn. 2008 Nov;118(11):664-9.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 204.5±23.0 °C at 760 mmHg
Molecular Formula C7H5NOS
Molecular Weight 151.186
Flash Point 77.5±22.6 °C
Exact Mass 151.009186
LogP 1.78
Vapour Pressure 0.2±0.4 mmHg at 25°C
Index of Refraction 1.745
Storage condition 2-8°C

 Safety Information

Symbol GHS07 GHS08
GHS07, GHS08
Signal Word Warning
Hazard Statements H317-H361
Precautionary Statements P280
Personal Protective Equipment Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes T,Xn
Risk Phrases 61-42/43-63
Safety Phrases 53-22-36/37/39-45-36/37
RIDADR 3249
WGK Germany 3
RTECS CI9000000
Packaging Group II

 Articles64

More Articles
Complete sequencing and characterization of 21,243 full-length human cDNAs.

Nat. Genet. 36 , 40-5, (2004)

As a base for human transcriptome and functional genomics, we created the "full-length long Japan" (FLJ) collection of sequenced human cDNAs. We determined the entire sequence of 21,243 selected clone...

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

Genome Res. 14 , 2121-7, (2004)

The National Institutes of Health's Mammalian Gene Collection (MGC) project was designed to generate and sequence a publicly accessible cDNA resource containing a complete open reading frame (ORF) for...

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

Anal. Chem. 81(11) , 4493-501, (2009)

The analysis of proteome-wide phosphorylation events is still a major analytical challenge because of the enormous complexity of protein phosphorylation networks. In this work, we evaluate the complem...

 Synonyms

IUB: 3.5.4.4
Benzisothiazolone
L-ASPARAGINASE
T56 BSMVJ
ASPARAGINASE
benzo[d]isothiazol-3-one
1,2-Benzisothiazol-3(2H)-one
EC 3.5.1.1
T56 BSNJ DQ
crasnitin
L-ASPARAGINE AMIDOHYDROLASE
1,2-Benzothiazol-3(2H)-one
elspar
1,2-Benzisothiazol-3-ol
1,2-Benzothiazol-3-ol
Benzisothiazolone (BIT)
colaspase
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